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EXHIBIT ID: CI_A_1008

Cerebral Small Vessel Disease

Animation of the effects of high blood pressure on the small perforating arteries within the brain leading to stretching, thinning, plaque formation, vascular narrowing and clot formation eventually causing ischemic stroke.

circulatory circulation brain cerebral small vessel disease perforating high blood pressure hypertension arteries artery vessels stretched stretching thinning thinned walls plaque formation narrowing narrow clot block blockage stroke ischemic ischemia damage