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EXHIBIT ID: OB_A_1022

Pre-existing Conditions Fetus Animation

Animation depiction of a pre-existing condition of amniotic fluid infection affecting the fetus. This infection causes iscemic changes in the placenta membrane resulting in blood clots and tissue necrosis.

infant fetus baby infection pre-existing condition mother amniotic fluid iscemia iscemic immune response immune system blood clots tissue necrosis inflammation vasculitis chorionic chorionic vessels placenta umbilicus umbilical cord perivascular tissue Wharton's jelly plate stroma nucleated red blood cells meconium macrophages maternal oxygen blood utero-placental underperfusion malperfusion response slow reaction neutrophils